HEMODYNAMIC BENEFITS OF LONG-TERM BUNAZOSIN (ALPHA-1 BLOCKER) THERAPY IN RATS WITH MYOCARDIAL INFARCTION AND HEART FAILURE
スポンサーリンク
概要
- 論文の詳細を見る
To determine whether bunazosin (α_1-adrenoceptor blocking agent) can alter the hemodynamic profile of chronic heart failure secondary to myocardial infarction, the drug was administered to Wistar rats 4 weeks after coronary ligation, and continued for 4 weeks. In rats without bunazosin treatment, the left ventricular end-diastolic pressure (LVEDP) and the total vascular resistance index (TVRI) increased as a function of infarct size, while the cardiac index (CI) decreased. But in infarcted rats with bunazosin treatment, the mean aortic pressure and TVRI were reduced, the LVEDP was modestly lessened, and the CI was maintained. The greatest increase in CI after the treatment occurred in rats with infarcts of small and moderate size. Thus, long-term therapy with bunazosin improved LV dysfunction, relative to the size of infarction. This study suggests the beneficial effects of bunazosin therapy in patients with chronic heart failure.
- 社団法人日本循環器学会の論文
- 1989-04-20
著者
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Kusukawa Reizo
The Department Of Cardiology Tenri Hospital
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UMEMOTO Seiji
the Second Department of Internal Medicine, Yamaguchi University School of Medicine
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Kusukawa R.
Yamaguchi University School Of Medicine
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Fukuta Shinji
The Second Division Department Of Internal Medicin Yamaguchi University School Of Medicine
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TOMA Yoichi
The second Department of Internal Medicine, Yamaguchi University School of Medicine
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KUSUKAWA Reizo
The second Department of Internal Medicine, Yamaguchi University School of Medicine
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Umemoto Seiji
The Department Of Medical Bioregulation Division Of Cardiovascular Medicine Yamaguchi University Sch
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Umemoto Seiji
Second Dept.of Int.med. Yamaguchi University School Of Medicine
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Toma Yoichi
Yamaguchi National Hospital and Internal Medicine Yamaguchi Univ. School of Medicine
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Umemoto Seiji
Yamaguchi National Hospital and Internal Medicine Yamaguchi Univ. School of Medicine
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Itagaki Tatsunori
The Second Department of Internal Medicine, Yamaguchi University School of Medicine
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YAMAKAWA KATSUTOSHI
The Second Department of Internal Medicine, Yamaguchi University School of Medicine
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YOSHINAGA TOSHIKO
The Second Department of Internal Medicine, Yamaguchi University School of Medicine
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Yoshinaga Toshiko
Second Division, Department of Internal Medicine, Yamaguchi University
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Fukuta Shinji
Department Of Internal Medicine Yamaguchi University School Of Medicine.
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Itagaki Tatsunori
Department Of Internal Medicine Yamaguchi University School Of Medicine.
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Toma Yoichi
The 2nd Dept.of Int.med. Yamaguchi University
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Toma Yoichi
The Second Division Of Internal Medicine Yamaguchi University School Of Medicine
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Fukuta Shinji
The Second Department Of Internal Medicine Yamaguchi University School Of Medicine
-
Fukuta Shinji
Department Of Internal Medicine Yamaguchi University School Of Medicine
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Kusukawa Reizo
The Second Department Of Internal Medicine Yamaguchi University School Of Medicine
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Umemoto Seiji
The Second Department Of Internal Medicine University Of Yamaguchi
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Toma Yoichi
The Second Department Of Internal Medicine Yamaguchi University School Of Medicine
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Kusukawa Reizo
Department Of Cardiology Tenri Hospilal
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Tohma Y.
Yamaguchi National Hospital And Internal Medicine Yamaguchi Univ. School Of Medicine
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Fukuta Shinji
山口大学 内科
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Kusukawa Reizo
Central Lab. Kyoto Univ. Hosp.
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Yoshinaga Toshiko
The Second Division Department Of Internal Medicin Yamaguchi University School Of Medicine
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Yoshinaga Toshiko
Second Division Department Of Internal Medicine Yamaguchi University
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Yamakawa Katsutoshi
Yamaguchi University School Of Medicine
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Yamakawa Katsutoshi
Department Of Internal Medicine Yamaguchi University School Of Medicine
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