ORAL VERAPAMIL EFFECTS ON GLOBAL AND REGIONAL LEFT VENTRICULAR DIASTOLIC FILLING IN HYPERTROPHIC CARDIOMYOPATHY

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概要

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• To assess the effects of oral verapamil therapy on global and regional left ventricular (LV) diastolic filling of hypertrophic cardiomyopathy (HCM), we studied 9 patients with HCM by radionuclide ventriculography and M-mode echocardiography before and after 2 weeks of oral verapamil therapy (240 mg/day). LV regional function was assessed by subdividing the LV region of interest into 4 regions from which global, septal, apical and lateral time-activity curves and their first-derivative curves were derived. Diastolic asynchrony during early diastole was measured as the sum of the absolute values (total Δt) of the time differences ( Δt) from peak filling rate in the global left ventricle to that in each of the 3 regions. Verapamil did not alter LV systolic function globally and regionally. Global LV peak filling rate improved after verapamil therapy from 1.92±0.59 to 2.35±0.63 end-diastolic counts/s (p<0.02) without altering regional peak filling rates significantly. Global and regional times to peak filling rate showed a shortening or no change despite a tendency to increase in the diastolic time after verapamil therapy. The total Δt decreased from 93±61 to 41±23 ms after verapamil (p<0.05), indicating more synchronous LV diastolic filling after verapamil. There was a negative correlation between the global peak filling rate and the total Δt (r= -0.54, p<0.05, n=18), suggesting that the global peak filling rate may improve after verapamil therapy in association with the decrease in the asynchronous LV diastolic filling. Thus, verapamil was effective in improving impaired LV filling in HCM, which might be related to reduction in regional LV diastolic asynchronous filling.

• 社団法人日本循環器学会の論文
• 1990-11-20

著者

• Yamamoto Takeshi

  Department Of Medicine And Clinical Science Division Of Cardiology Yamaguchi University Graduate Sch

• KUSUKAWA REIZO

  Japanese Circulation Society(JCS)Task Force Committee on Chronic Myocarditis

• Kusukawa Reizo

  Department Of Cardiology Tenri Hospital

• Kusukawa Reizo

  The Department Of Cardiology Tenri Hospital

• Kusukawa R.

  Yamaguchi University School Of Medicine

• OZAKI MASAHARU

  Second Department of Internal Medicine, Yamaguchi University

• YAMAGISHI TAKASHI

  Second Department of Internal Medicine, Yamaguchi University

• Obayashi Masakazu

  Division Of Cardiovascular Medicine Department Of Medical Bioregulation Yamaguchi Univesity Graduate

• Ozaki Masaharu

  2nd. Dept. Of Internal Med. Yamaguchi Univ. Ube Yamaguchi Japan

• KUSUKAWA REIZO

  Second Department of Medicine, Yamaguchi University School of Medicine

• Kusukawa R

  Department Of Cardiology Tenri Hospital

• Kusukawa R

  The 2nd Departmen Of Internal Medicine Yamaguchi University School Of Medicine

• Kusukawa Reizo

  The Second Department Of Internal Medicine Yamaguchi University School Of Medicine

• Kusukawa Reizo

  Second Department Of Internal Medicine Yamaguchi University School Of Medicine:national Hamada Hospi

• Kusukawa Reizo

  Department Of Cardiology Tenri Hospilal

• Kusukawa Reizo

  Departmet Of Cardiology Tenri Hospital

• Ozaki Masaharu

  Second Department Of Internal Medicine Yamaguchi University

• Yamamoto Takeshi

  Division Of Cardiovascular Medicine Department Of Medical Bioregulation Yamaguchi University School

• Ozakl Masaharu

  Department Of Internal Medicine Yamaguchi University School Of Medicine

• Kusukawa Reizo

  Tenri Hosp. Div. Of Cardiol. Tenri. Nara Prfe

• Kusukawa Reizo

  Central Lab. Kyoto Univ. Hosp.

• Obayashi Masakazu

  Department Of Medical Bioregulation Division Of Cardiovascular Medicine Yamaguchi University School

• Obayashi Masakazu

  Department Of Medical Bioregulation Division Of Cardiovascular Medicine Yamaguchi University School

• Yamamoto Takeshi

  Division Of Cardiology Tokuyama Central Hospital

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