EFFECTS OF DIALYSIS ON LEFT VENTRICULAR DIASTOLIC FILLING IN PATIENTS WITH CHRONIC RENAL FAILURE : Assessment with Radionuclide Ventriculography

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概要

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• To examine the effects of dialysis on left ventricular (LV) filling, gated radionuclide ventriculography was conducted in 15 patients with renal failure before and after dialysis. The LV regional function was assessed by subdividing the LV region of interest into 4 regions from which global and regional time-activity curves and their first-derivative curves were obtained. Early diastolic asynchrony was measured as the sum of the absolute values (total Δt) of the time differences (Δt) between the global peak LV filling rate (PFR) and that for each of the other 3 regions. Dialysis produced an increase in the peak LV ejection rate (PER), heart rate, total Δt and total Δt/diastolic time. It caused a delay or tendency to delay in the time to PFR without significant changes in the PFR either globally or regionally, and the PFR/PER ratio decreased both globally and regionally. These alterations indicated a failure of improvement of the global and regional LV filling, with more asynchronous filling occurring after dialysis despite the increases in PER and,heart rate, both of which are expected to increase PFR and shorten the time to PFR. There was a negative correlation between the change in total Δ t/diastolic time and the change in the PFR/PER ratio (r= -0.62, p<0.01), with a greater increase in asynchrony occurring with the relative greater reduction in the relative global PFR compared with the global PER after dialysis. Dialysis can produce early diastolic asynchronous filling, which will be associated with a failure of improvement of LV filling despite the increases in LV peak ejection rate and the heart rate. Thus, LV filling requires careful attention in patients undergoing dialysis, since the pattern and timing of the filling is altered, and the excessive water removal by dialysis may affect the LV diastolic filling.

• 社団法人日本循環器学会の論文
• 1990-11-20

著者

• Yamamoto Takeshi

  Department Of Medicine And Clinical Science Division Of Cardiology Yamaguchi University Graduate Sch

• KUSUKAWA REIZO

  Japanese Circulation Society(JCS)Task Force Committee on Chronic Myocarditis

• Kusukawa Reizo

  Department Of Cardiology Tenri Hospital

• Kusukawa Reizo

  The Department Of Cardiology Tenri Hospital

• Kusukawa R.

  Yamaguchi University School Of Medicine

• Obayashi Masakazu

  Division Of Cardiovascular Medicine Department Of Medical Bioregulation Yamaguchi Univesity Graduate

• Ozaki Masaharu

  2nd. Dept. Of Internal Med. Yamaguchi Univ. Ube Yamaguchi Japan

• Kusukawa R

  Department Of Cardiology Tenri Hospital

• Kusukawa R

  The 2nd Departmen Of Internal Medicine Yamaguchi University School Of Medicine

• Yuki Kenichi

  Second Department Of Internal Medicine Yamaguchi University School Of Medicine:national Hamada Hospi

• Kusukawa Reizo

  The Second Department Of Internal Medicine Yamaguchi University School Of Medicine

• YAMAGISHI TAKASHI

  The National Hamada Hospital and University of Yamaguchi

• YUKI KENICHI

  The National Hamada Hospital and University of Yamaguchi

• OZAKI MASAHARU

  The National Hamada Hospital and University of Yamaguchi

• KUSUKAWA REIZO

  The National Hamada Hospital and University of Yamaguchi

• Kusukawa Reizo

  Second Department Of Internal Medicine Yamaguchi University School Of Medicine:national Hamada Hospi

• Kusukawa Reizo

  Department Of Cardiology Tenri Hospilal

• Kusukawa Reizo

  Departmet Of Cardiology Tenri Hospital

• Yamamoto Takeshi

  Division Of Cardiovascular Medicine Department Of Medical Bioregulation Yamaguchi University School

• Ozakl Masaharu

  Department Of Internal Medicine Yamaguchi University School Of Medicine

• Kusukawa Reizo

  Tenri Hosp. Div. Of Cardiol. Tenri. Nara Prfe

• Kusukawa Reizo

  Central Lab. Kyoto Univ. Hosp.

• Obayashi Masakazu

  Department Of Medical Bioregulation Division Of Cardiovascular Medicine Yamaguchi University School

• Obayashi Masakazu

  Department Of Medical Bioregulation Division Of Cardiovascular Medicine Yamaguchi University School

• Yamamoto Takeshi

  Division Of Cardiology Tokuyama Central Hospital

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