Repetitive Coxsackievirus Infection Induces Cardiac Dilatation in Post-Myocarditic Mice
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概要
- 論文の詳細を見る
The relation between mycarditis and dilated cardiomyopathy(DCM)is controversial. To clarify the pathogenic mechanism of these diseases, the present study examined the effect of repetitive inoculation with coxsackievirus B3(CVB3)in post-myocarditic mice. Inbred 3-week-old A/J mice were inoculated intraperitoneally with CVB3(Nancy strain;2×10^4 plaque-forming units)and reinfected in the same manner with CVB3 at 40 weeks (3W+/40W+). All mice were killed at 42 weeks old. The weight of the hearts of the 3W+/40W+ group were significantly increased compared with those of the 3W-/40W+ group, and both the heart weight/body weight and lung weight/body weight ratios of the 3W+/40W+ group were also significantly increased over those of the 3W-/40W- group, although the levels of serum neutralizing antibody titers were significantly increased in the 3W+/40W+ group over the level of the other groups. No increase in inflammatory cell infiltration or fibrosis progression was observed in the 3W+/40W+group relative to the 3W+/40W- group, but the second inoculation resulted in a significant left ventricular dilatation and in left and right ventricular free wall thinning(3.31±0.20mm vs 2.61±0.19mm, p<0.05;0.54±0.09mm vs 0.72±0.16mm, p<0.05, respectively). The sarcomere length was also significantly increased in the 3W+/40W+ group compared with that of the other groups, as determined by electron microscopy. Degenerative or necrotic areas in the infectecd hearts were not stained with anti-mouse IgG antibody, but were stained, only in 3W+/40W+ mice, with anti-mouce IgM antibody. The concentrations of TNF-α in the hearts of the 3W+/40W+ group were increased significantly over those of the 3W+/40W- group. Repetitive CVB3 infection produced cardiac dilatation without inflammatory cell infiltration in post-myocarditic mice. Autoimmunity mediated by the circulation of certain antibodies(eg, antibodies against CVB3 genome or a CVB3-related protein)may be part of the pathogenic mechanism for this phenomenon. Thus, repetitive virus infection might contribute to the pathogenesis of cardiac dilatation.
- 社団法人日本循環器学会の論文
- 1999-09-20
著者
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Nakao Fumiaki
The Second Department Of Internal Medicine Yamaguchi University School Of Medicine Yamaguchi
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Nakao Fumiaki
The Second Department Of Internal Medicine
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UMEMOTO Seiji
the Second Department of Internal Medicine, Yamaguchi University School of Medicine
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MATSUZAKI Masunori
the Second Department of Internal Medicine, Yamaguchi University School of Medicine
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Yamaguchi Kazuhito
Institute Of Laboratory Animals Yamaguchi University Graduate School Of Medicine
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Umemoto Seiji
Pharmaceutical Clinical Research Center Yamaguchi University Hospital
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Yamamoto K
Rheumatology Immunology And Genetics Program Institute Of Medical Science St. Marianna University
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Nakamura Hiroshi
The Second Department of Internal Medicine
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Yamamoto Takuo
The Second Department of Internal Medicine
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Yamamura Taisei
The Second Department of Internal Medicine
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Shintaku Takao
Institute of Laboratory Animals, Yamaguchi University School of Medicine
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Liu Peter
The Toronto General Hospital, University of Toronto
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Shintaku Takao
Institute Of Laboratory Animals Yamaguchi University School Of Medicine
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Yamamoto Takuo
The Department Of Medical Bioregulation Division Of Cardiovascular Medicine Yamaguchi University Sch
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Yamamura Taisei
The Department Of Medical Bioregulation Division Of Cardiovascular Medicine Yamaguchi University Sch
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Yamamura Taisei
Second Department Of Medicine Yamaguchi University
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Umemoto Seiji
The Department Of Medical Bioregulation Division Of Cardiovascular Medicine Yamaguchi University Sch
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Umemoto Seiji
Second Dept.of Int.med. Yamaguchi University School Of Medicine
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Umemoto Seiji
Yamaguchi National Hospital and Internal Medicine Yamaguchi Univ. School of Medicine
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Liu Peter
The Toronto General Hospital University Of Toronto
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Matsuzaki Masunori
The Second Department Of Internal Medicine University Of Yamaguchi
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Umemoto Seiji
The Second Department Of Internal Medicine University Of Yamaguchi
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Nakamura Hiroshi
Division Of Cardiology Yamaguchi University Graduate School Of Medicine
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Yamaguchi Kazuhito
Department Of Bioregulation And Proteomics Institute Of Medical Science St. Marianna University Scho
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Nakamura Hiroshi
The Department Of Medical Bioregulation Division Of Cardiovascular Medicine Yamaguchi University Sch
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