A CASE OF MYOCARDIAL DAMAGE FOLLOWING ACUTE PARACETAMOL POISONING

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概要

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• A 24-year-old woman was admitted to our hospital with acute paracetamol poisoning, and severe hepatic injury. The peak blood level f GOT, GPT and LDH were 32,600 U, 119,200 U and 36,500 U respectively. Glucagon-insulin and glutathione were administered to save the liver function. On the third hospital day, hemodialysis was administered to treat acute renal failure. On the 16th hospital day, when the liver and renal functions recovered, severe pulmonary congestion occurred and right heart catheterization revealed high pulmonary pressure. Echocardiography showed left ventricular wall motion. Multi-focal ventricular arrhythmia was frequent during this period. hemodialysis and artificial respiration were carried out for the treatment of heart failure. Three months after admission, myocardial perfusion scintigram showed patchy reduction i the uptake of T1-201 throughout the myocardium, and left ventriculography showed mild diffuse impairment of the LV wall motion (ejection fraction: 49%). in this case, acute heart failure appeared approximately 2 weeks after the severe hepatic injury. Apparently myocardial damage following paracetamol overdosage is caused not only by direct toxicity but by severe metabolic derangement.

• 社団法人日本循環器学会の論文
• 1989-03-20

著者

• Yano Masafumi

  Department Of Medicine And Clinical Science Division Of Cardiology Yamaguchi University Graduate Sch

• Kusukawa Reizo

  The Department Of Cardiology Tenri Hospital

• MATSUZAKI Masunori

  the Second Department of Internal Medicine, Yamaguchi University School of Medicine

• Kusukawa R.

  Yamaguchi University School Of Medicine

• Otani Nozomu

  2nd Department Of Internal Medicine Yamaguchi University School Of Medicine

• ANNO Yoshito

  The second Department of Internal Medicine, Yamaguchi University School of Medicine

• KUSUKAWA Reizo

  The second Department of Internal Medicine, Yamaguchi University School of Medicine

• MATSUDA YASUO

  The Second Department of Internal Medicine, University of Yamaguchi

• Ohtani Nozomu

  The Second Department of Internal Medicine Yamaguchi University School of Medicine

• Otani Nozom

  The Second Depertment Of Internal Medicine Yamaguchi Univrsity School Of Medicine

• Anno Yoshito

  Division Of Cardiology Saiseikai Yamaguchi General Hospital

• Kusukawa Reizo

  The Second Department Of Internal Medicine Yamaguchi University School Of Medicine

• Ogawa Hiroshi

  The Second Division of Internal Medicine, Yamaguchi University School of Medicine

• Matsuzaki Masunori

  The Second Department Of Internal Medicine University Of Yamaguchi

• Kusukawa Reizo

  Department Of Cardiology Tenri Hospilal

• Anno Y.

  The Second Department Of Internal Medicine Yamaguchi University School Of Medicine

• Kusukawa Reizo

  Central Lab. Kyoto Univ. Hosp.

• Otani Nozom

  The Second Depertment Of Internal Medicine

• Anno Y.

  The Depart. Of Int. Med. Yamaguchi Univers. School Of Med.

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