THE INHIBITORY EFFECT OF LIPID PEROXIDE ON THE ACTIVITY OF THE MEMBRANE-BOUND AND THE SOLUBILIZED LIPOPROTEIN LIPASE
スポンサーリンク
概要
- 論文の詳細を見る
The effect of lipid peroxide (15-hydroperoxy arachidonic acid) on the activity of lipoprotein lipase was investigated. The activities were examined in 2 enzyme species : the lipoprotein lipase bound to the coronary vessels of the rat heart and that solubilized in the human post-heparin plasma. As a substrate, ^3H-labelled human chylomicron was used. Lipid peroxide decreased the maximal velocity of the reaction between the chylomicron and lipoprotein lipase on the vascular surface. In the post-heparin plasma, the lipid peroxide decreased the maximal hydrolysis rate, but did not change the half life time in the unsaturated reaction. It is suggested that lipid peroxide directly damages a part of the membrane-bound lipoprotein lipase, and that the degeneration of cell membranes and the vasoconstriction caused by lipid peroxide will additionally disturb the hydrolysis of the plasma triglyceride on the vascular surface.
- 社団法人日本循環器学会の論文
- 1983-07-20
著者
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Miki Hideo
Department Of Internal Medicine Yamaguchi University School Of Medicine
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Kusukawa Reizo
Department Of Cardiology Tenri Hospital
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Kusukawa R.
Yamaguchi University School Of Medicine
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Wada Kazunari
Department Of Internal Medicine Yamaguchi University School Of Medicine
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Okuda Fumio
Department of Internal Medicine, Yamaguchi University School of Medicine
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Kumada Toshiaki
The Third Department Of Internal Medicine Faculty Of Medicine Kyoto University
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ETOH MASAHIKO
Department of Internal Medicine, Yamaguchi University School of Medicine
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KUMADA TOSHIAKI
Department of Internal Medicine, Yamaguchi University School of Medicine
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Kumada Toshiaki
The 3rd Medical Clinic Kyoto University Hospital
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Kumada Toshiaki
Department Of Internal Medicine Yamaguchi University School Of Medicine
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Okuda Fumio
The 2nd Dep. Of Int. Med. Yamaguchi Univ. Sch. Of Med
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Okuda Fumio
The 2nd Dept. Of Int. Med. Yamaguchi Univ. School Of Med.
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Okuda Fumio
Department Of Internal Medicine Yamaguchi University School Of Medicine
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Kusukawa Reizo
Department Of Internal Medicine Yamaguchi University School Of Medicine
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Etoh Masahiko
Department Of Internal Medicine Yamaguchi University School Of Medicine
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Kumada Toshiaki
The 2nd Department Of Internal Medicine Faculty Of Medicine Yamaguchi University
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Kumada Toshiaki
The Division Of Internal Medicine Yamaguchi University School Of Medicine
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Kusukawa Reizo
Department Of Cardiology Tenri Hospilal
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Wada Kazunari
Dept. Of Med. Yawaguchi Univ. School Of Med
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Wada K
Onoda Red-cross Hospital
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Okuda Fumio
Department of Hydrocarbon Chemistry, Faculty of Engineering, Kyoto University
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