ELECTROPHYSIOLOGICAL EFFECTS OF NICARDIPINE HYDROCHLORIDE ON THE ISOLATED SINOATRIAL AND ATRIOVENTRICULAR NODES OF THE RABBIT

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概要

• 論文の詳細を見る

• The electrophsiological effects of nicardipine-HCl, a new calcium antagonist and potent vasodilator, were studied in the isolated sinoatrial (SA) and atrioventricular (AV) nodes of the rabbit in an oxygenated Tyrode solution at 35℃ using an intracellular microelectrode technique. Nicardipine-HCl decreased the spontaneous rate of the SA node and prolonged sinus recovery time, dose-dependently. The effective refractory period (ERP) and functional refractory period (FRP) of the AV node and AV conduction time (A-H interval) were also prolonged by nicardipine-HCl in a dose-dependent manner. In conclusion, nicardipine-HCl has electrophysiological effects on the SA and the AV node similar to those of other calcium antagonists in the excised and superfused rabbit heart.

• 社団法人日本循環器学会の論文
• 1983-07-20

著者

• Kawai Chuichi

  The Kyoto And Shiga Myocardial Infarction (kysmi) Study Group:kyoto University

• Kawai Chuichi

  The Third Division Department Of Internal Medicine. Faculty Of Medicine Kyoto University

• KONISHI TOMOTSUGU

  The Third Department of Internal Medicine, Kyoto University Hospital

• Matsuda Hiroko

  The Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University

• Konishi Tomotsugu

  The Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University

• Konishi Tomotsugu

  3rd Div. Dept. Of Intern. Med Faculty Of Med. Kyoto Univ.

• Konishi Tomotsugu

  The Third Department Of Internal Medicine Kyoto University Hospital

• Tamamura Toshitake

  The Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University

• Kawai Chuichi

  The Third Department Of Internal Medicine Faculty Of Medicine Kyoto University

• KADOYA MAKOTO

  The Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University

• YOKOYAMA SHOICHI

  The Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University

• Kadoya Makoto

  The Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University

• Konishi Tomotsugu

  3rd Div. Dept. Int. Med. Faculty Of Medicine Kyoto University

• Yokoyama Shoichi

  The Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University

• Konishi Tomotsugu

  Dept. Of Intern. Med. Kyoto Univ. Hosp.

• Tamamura Toshitaka

  The Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University

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