植物ホルモン生合成阻害剤の戦略的創製研究(学会賞)

概要

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Development of chemicals that induce phenotypes of interest is now emerging as a useful way to study biological systems in plants and this would be a complement to classical biochemical and genetic methods. Exploring the small molecules that induce brassinosteroid (BR) deficient-like phenotype in Arabidopsis led us to identify a couple of BR biosynthesis inhibitors. They allow the investigation of the functions of BRs in a variety of plant species. Application of BR biosynthesis inhibitors to a standard genetic screen to identify mutants that confer resistance to these inhibitors allowed the identification of new components working in BR signal transduction. Next, we started the screening of ABA biosynthesis or ABA catabolism inhibitors. One of the inhibitors that targeting carotenoid cleaving enzyme existing in the upstream of ABA biosynthesis pathway was found to be a new ABA biosynthesis inhibitor. Intensive screening of ABA catabolism inhibitors among various triazole derivatives led us to find some of inhibitors targeting ABA 8'-hydroxylase. Both of them will be useful for investigating new functions of ABA and isolating new mutants of ABA signal transduction.
植物化学調節学会の論文
2004-10-13