2.追加リウマチ患者の関節液中補体価(第3回補体シンポジウム II 各種疾患における補体及び補体成分の変動)

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It is said that the whole complement titer in the synovial in rheumatoid arthritis markedly decreases in patients with the disease active. The purpose of this investigation was to study the relationship between the inflammatory activites of the disease and complement value in synovial fluid. Sera and synovial fluif were obtained from 6 normal control subjects, 37 patients with rheumatoid arthritis and 20 patients with Ostioartlevits. They were separated into 15 for classical RA, 13 for definite RA and 9 for possible RA according to the American Rheumatism Association's criteria. All the patients with osteoarthritis had the characteristic history of non-infectious arthritis, typical radiographic and synovial fluid findings. Synovial fluid was obtained aseptically by aspitation of the suprapatellar pourch and blood was drawn at the same time by venepuncture. Then, the patient' sera and synovial fluid complement activity were measured by C'H50 method of Mayer's. The amount of the total protein in the synovial fluid was measured on a Beckman spectrophotometer, model DU2, at wave lengths of 280 mμ. Serum C' values of all the rheumatoid arthritis but one were slightly elevated and gave a median value of 45.2 unit. On the other hand, the majority of serum C' values of the 20 patients with osteoarthritis were within normal range (median value 37.5 unit). Synovial fluid complement values in the 6 normal control subjects ranged from 6 units to 10 units (median value 8 unit). The synovial fluid C' value of the patiens with osteoarthritis ranged from 12 to 20 units and had a median value of 13.6 unit. The greater the inflammatory syntomes, the greater the amount of C' activity in synovial fluid and as inflammatory symptoms subsided and volume of fluid or total protein concentration in synovial fluid reduced, then C' activity fell gradually toward the normal range. The synovial C' titer seemed to be directly related to the activity of local inflammation in osteoarthritis. Forty-three synovial fluids in the 37 patients with rheumatoid arthritis revealed various complement activities ranging from 35 units to 0 unit. In one-third of the tested subjects, the C' activity was less than the values in normal synovial fluid. In 10 patients with hfeumatoid arthritis examined eary in the course of the arhritis, initial synovial fluid C' levelswere incresed uniformly and significantly in proportion to the degree of inflammation, but with the passage of time, the C' levels in these synovial fluids decreased rapidly, in spit of continuance of the disease activity. Although, the protein concentrationo in these cases was elevated over a range of osteoarthritis, the synovial fluid complement values were quite low. This might be an evidence for a local antigen-antibody reaction utilizing complement in rhematoid arthritis. In several patient with chronic rheumatoid arthritis and persitient effusions (so called a state of "hydrops"), complement activities in synovial fluid were relatively high and followed the course similar to that of osteoarthritis.
一般社団法人日本アレルギー学会の論文
1966-11-30

2.追加リウマチ患者の関節液中補体価(第3回補体シンポジウム II 各種疾患における補体及び補体成分の変動)

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2.追加 リウマチ患者の関節液中補体価(第3回補体シンポジウム II 各種疾患における補体及び補体成分の変動)

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2.追加リウマチ患者の関節液中補体価(第3回補体シンポジウム II 各種疾患における補体及び補体成分の変動)