ヒト血清補体の研究 : 第1報.健康集団における血清補体価ならびにその日内変動

概要

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1. Human hemolytic complement activity was measured by Mayer's CH_<50> method in human sera obtained from 854 healthy Japanese children and adults. The result indicated that mean value of CH_<50> was 35.8 units per milliliter (29.2-43.9 units per ml. with 1 σ). No serum was found showing more than 90 CH_<50> units/ml., though accurate titration was not performed in the sera with higher titer than 60 CH_<50> units /ml. Eleven out of 854 sera showed markedly low hemolytic complement activity of less than 2 CH_<50> units /ml. It was already reported by the author and others that some of these sera were deficient in the third component of complement (C_3). 2. While investigating the averages of CH_<50> in each age from six to sixty, it was noticed that CH_<50> increased in the ages of ten, eleven and twelve. However, no correlation between complement titer and sex or blood type was found. 3. The variation of CH_<50> during daytime was observed in 13 healthy volunteers and 12 patients with such diseases that were considered to have no influence upon serum complement level. The determination for CH_<50> in these subjects was made six times a day from 7 a.m. to 9 p.m. The results revealed that no significant difference between maximum and minimum values of diurnal variation was found in CH_<50> of each case.
1969-03-30