生下時胸腺摘出モルモットにおける遅延型皮内反応

概要

論文の詳細を見る
Within 24 hours following thymectomy or sham-operation, new-born guinea pigs were sensitized to tubercle bacilli or bovine serum albumin (BSA) by an intramuscular injection of 0.05 mg of tubercle bacilli in paraffin oil or of 0.1 mg of BSA in Freund's complete adjuvant. 1) The health of thymectomized guinea pigs was excellent during the period of observation. Thymectomized and sham-operated animals gained weight equally and steadily by ca. 6.2 gm a day. 2) Depression of the total blood leukocyte counts of the thymectomized guinea pigs differed signifi-cantly from the sham-operated ones at the P<0.01 level. Differential leukocyte counts indicated that a part of this depression, at least, was due to the decrease of small and medium size lymphocytes. 3) There was no inhibition of delayed sensitization in guinea pigs sensitized with tubercle bacilli after thymectomy at birth. Thymectomized guinea pigs had positive delayed skin reactions to BSA of intensity comparable to those in sham-operated animals. 4) Histologic studies revealed that thymus of guinea pigs at birth was fully developed showing cortical and medullary areas, and well-developed Hassall's corpuscles clearly.
日本アレルギー学会の論文
1966-09-30