濃厚ツベルクリンによる遅延型感作

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The main objective was to study the possibility of the delayed type sensitization in guinea pigs or rabbits by injecting the old tuberclin or the PPDs-slution intradermally. 1) One week after the sensitization by intracutaneous or subcutaneous injection with 0.1 ml of tenfold diluted old tuberculin, guinea pigs showed, when tested with the same solution, strong skin reactions appearing maximal at 18 or 24 hours. 2) This hypersensitivity began to appear 5 days after the sensitization and lasted as long four weeks, but there was no increase of humoral antibody titers in those weeks. 3) This hypersensitivity could be successfully transferred to normal guinea pisg with the intraperit-oneal exudate cells from the sensitized ones, but not with the sera from the same donors. 4) In rabbits this type of sensitization did not develop so easily as in guinea pigs, however, skin reaction began to increase in size when rabbits were injected intracutaneously two or three times with 0.1 ml of 1:5 diluted old tuberculin. 5) It can be seen from the above that this sensitization is not of a Arthus type but a delayed one. In relation to this sensitization, the significance of the Jones-Mote type hypersensitivity has been briefly discussed. Finally, our suggestion is that it should be avoided to inject the high concentration of tuber-culin into the same animal repeatedly repeatedly during the passive transfer experiment of tuberculin allergy for fear that recipients should be sensitized actively by tuberculin preparations.
日本アレルギー学会の論文
1966-02-28

濃厚ツベルクリンによる遅延型感作

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