薬物過敏症における試験管内血小板減少現象に関する研究 : 第二編臨床実験

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The in vitro changes in number of thrombocytes of various blood was studied in drug hypersensitive patients as it was thought to be one of the subsequenting phenomena of in vitro antigen antibody reaction. Forty-six cases with drug hypersensitivity 14 cases of penicillin-hypersensitivity, 16 cases of aminopyrin-hypersensitivity and 16 cases of PAS-hypersensivity and 40 non-sensitive cases as control were tested. One drop of the diluted drug was added to 2, 5 ml of oxalated blood and incubated at 37°C. The number of thrombocytes was counted at 0 time, 30 minutes, 1 hour, and 2 hours, after the mixture of blood antigen. The results obtained were as follows: 1) Decrease in thrombocyte count after the addition of penicillin, aminopyrin, and PAS-Na was within 20% in the control blood. 2) With penicillin-hypersensitive patient's blood, the mean decrease was 36, 2%, with aminopyrin-hypersensitive patient's blood 34, 1% and with PAS-hypersenitive patient's blood 30, 1% respectively, demonstrating the significant difference in comparison with above mentioned control values. 3) Mild agglutination of thrombocyte was occasionally observed during thrombocyte count in the cases of hyper-sensitive, however not a remarkable change was observed in the number of thrombocyte count. These facts suggest that the main cause of this phenomenon may be due to thrombocytolysis. 4) In the hyposensitized case with the desensitization of PAS, this phenomenon could not be observed. From these results the authors emphasize that it is one of the reliable and useful diagnostic methods of drug hypersensitivity.
日本アレルギー学会の論文
1962-01-30

薬物過敏症における試験管内血小板減少現象に関する研究 : 第二編臨床実験

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薬物過敏症における試験管内血小板減少現象に関する研究 : 第二編 臨床実験

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薬物過敏症における試験管内血小板減少現象に関する研究 : 第二編臨床実験