薬物過敏症における試験管内血小板減少現象に関する研究 : 第一編基礎的実験

概要

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In the recent years, it has been conceived that thrombocytes play some roles in clinical hypersensitivity. The authors studied on drug hypersensitivity of which "allergen" has a definite chemical structure, e. g. PAS-Na, penicillin and aminopyrin. The thrombocytes number was counted immediately and 2 hours after incubation of anticoagulated blood with estimated antigen. The counting followed Brecher's Method. The ratio of the thrombocytes number after incubation to the inital thrombocytes number was calculated:The results obtained were as follows: 1) Among anticoagulants, Na-oxalate and heparin, especially the former, were most suitable for this test. 2) There was no difference in thrombocyte counts of venous blood between drug hypersensitive patients and normal subjects. 3) There was no significant decrease of thrombocytes number in oxalated blood of normal subjects after incubation with small amount of penicillin, aminopyrin or PAS-Na.
日本アレルギー学会の論文
1962-01-30