気管支喘息におけるアレルゲンに対する抗体検索試験の臨床的意義の検討

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Clinical significance of the several allergologic tests as a detective method of causal agents in asthma were studied. The direct intracutaneous skin test, the Prausnitz-Kustner reaction, the eye test, the inhalative provocation test (I. P. T. ), in vitro thrombo- and leucopenic indexes and the hemagglutination test with Middlebrook's and B. D. B. method were carried out simultaneously in 23 cases of asthmatic patients in the symptomfree interval by means of the house dust extract from one same lot. 1) The incidence of positive test were as follows: Intracutaneous skin test 61% P. K. Reaction 52% I. P. T. 26% Eye test 13% In vitro Thrombopenic index 25% or more 31% In vitro Leucopenic index 20% or more 17% Middlebrook's test 17% B. D. B. test 67% 2) The intracutaneous skin test was considered to be useful as a screening test for the detection of causal agents in asthma since all the patients with one or more positive test out of four test, i. e. I. P. T. , eye test, P. K. reaction and thrombopenic phenomenon reacted also positive to intracutaneous test. A high correlation coefficient was obtained between the skin test and P. K. reaction. 3) The results of eye test showed a close relationship to those of I. P. T. , and all of the 3 patients with positive eye test reacted positive to I. P. T. , P. K. reaction, and to thrombopenic phenomenon. However, there were three cases in which the eye test was negative while the I. P. T. was positive. 4) The results of thrombopenic phenomenon "in vitro" showed statistically significant relationship to those of the I. P. T. and the eye test. 5) No relationship was observed between the hemagglutination test and the other tests. Therefore, neither Middlebrook's method nor B. D. B. method seemed to be effective for the detection of skin sensitizing antibody to house dust in vitro.
日本アレルギー学会の論文
1965-06-30

気管支喘息におけるアレルゲンに対する抗体検索試験の臨床的意義の検討

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