アレルギー性胃腸障害(Gastrointestinopathia allergica)についての臨床的ならびに実験的研究 : 消化管のレ線所見・組織所見および消化吸収能を中心として

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Gastrointestinopathia allergica (G.A.) is defined as gastrointestinal disorders due to ingestion of speciffic food allergens, manifested by abdominal pain and gurgles, sensation of abdominal distension, nausea, vomiting, diarrhea etc. There is, however, no objective and practical method for diagnosis enabling to trace exactly the course of the antigen-antibody reaction involved in it. Initially, the results of some clinical examinations of allergy hitherto employed were discussed. Further, the roentgenological examination of the whole digestive tract of the patients performed during the period of allergic provocation revaled the following disturbances, namely, prolongation of gastric emptying time, decrease of gastric tonicity and motility, hyperkinesis, flocculation, dystonia and muddy appearances of the small intestine, as well as "sausage-like" pattern of the large intestine demonstrating no haustra formation. In addition, absorption study by radio activity determination in circulating blood of patients following the administration of RISA displayed a fall of absorption during provocation, compared with the result of control study. Likewise, decrease of absorption rate of fat as well as of protein was demonstrated in those rabbits and rats, which were sufficiently sensitized, manifesting a reduction of circulatory antibody titer by more than 50 per cent after provocation. Histological examination of the proximal jejunum excised from the sensitized rabbits and rats during provocation confirmed manifestation of enteritis comprising cellular infiltration in the lamina propria, submucosal edema, deformation of the villi and decreased alkalinephosphatase activity in the epithelial cells. Electronmicroscopic study disclosed irregularly distributed microvilli and comparatively less densely demonstrated matrix of mitochondria and reticulum. the results obtained in the present experiments led to the conclusion that on acue enteritis developed in the patients with G.A. and the sensitized animals during peroral provocation, resulting in a reduction of absorptive activity in the small intestine.
日本アレルギー学会の論文
1965-09-30

アレルギー性胃腸障害(Gastrointestinopathia allergica)についての臨床的ならびに実験的研究 : 消化管のレ線所見・組織所見および消化吸収能を中心として

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