Biochemical Analyses of Some Metabolites in Urine and Blood in Persons Exposed Accidentally to a Source of ^<192>Ir

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Eleven biochemical indicators (5-hydroxyindoleacetic acid, xanthurenic acid, creatine, creatinine, β-aminoisobutyric acid, taurine, 11-deoxy-17-ketosteroid, total estrogens and Dische reaction-positive substance(s) in urine; 5-hydroxytryptamine in whole blood; and cortisol in blood plasma) of the 'radiation injury' were analyzed in 6 cases which were accidentally exposed to a gamma ray source of 192Ir. Among them, 4 indicators including 5-hydroxyindoleacetic acid, taurine and Dische reaction-positive substance(s) in urine and 5-hydroxytryptamine in whole blood reflected the severity of the injury to some extent for long period far after the exposure: (1) Urinary excretion of 5-hydroxyindoleacetic acid was less than that of non-irradiated persons from days 11 to 17 after the exposure and increased to several times more than those of the non-irradiated in the subsequent week (days 17 to 25). (2) Blood levels of 5-hydroxytryptamine were minimal at the day 24th after the exposeure in the 2 cases (S.H. and Y.S.) which were exposed to higher doses. (3) The ratio of urinary taurine over alanine remained high in the two higher dose cases for several weeks of the post-irradiation period and returned to normal level thereafter. (4) The ratio of Dische reaction-positive substance(s) to creatinine in urine was high in the same two cases during 8 to 13 weeks of the post-irradiation.
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