Theory of Radiation Effect on Cell Populations in Intestinal Epithelium

概要

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Some simple mathematical models were developed to analyze the kinetics of the cell populations in the intestinal epithelium after an exposure to ionizing radiation. For the proliferative cells in crypt a logistic proliferation was assumed and for the functional cells in villus the compartment was assumed to be a first in-first out type. A feedback mechanism is introduced between the two compartments. Mechanisms of the effects of radiation on the system were considered by cell deaths, including delayed deaths, and by mitotic delay. The calculated results showed reasonable amount of over-shoot in the cell numbers in the recovery period and were in general consistent with the experiment.
日本放射線影響学会の論文