Modification of Radiation Lethality in Mice by Antithrombocyte Serum Injection

概要

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Anti-thrombocyte serum administered intraperitoneally to mice reduces thrombocyte count in 2 hours; after 3 days the count starts to recover, reaching a maximum level on day 7 after the treatment. The injection of anti-thrombocyte serum before or after x-irradiation modifies not only the extent of radiation-induced thrombocytopenia of the treated animals but also their sensitivity against the lethal effect of x-rays. The extent of thrombocytopenia on day 10 post-irradiation was minimized when the antiserum was administered to mice 2 hours or 1 day before irradiation (400 R). The survival rate of animal on day 30 was the highest when the antiserum was administered to mice 1 day before irradiation (750 R). The results suggest that the modification of radiation lethality by anti-thrombocyte serum injection is resulted from the modification of thrombocyte dynamics.
日本放射線影響学会の論文