細胞のin Vitroにおける放射線感受性におよぼす5-Hydroxytryptophanの影響

概要

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Possible protective effect of 5-hydroxytryptophan against radiation damage was examined in vitro, using the ascites tumor type Furth's mastcytoma cells which have the ability to synthesize 5-hydroxytryptamine and Ehrlich ascites tumor cells not having such ability. Protective effect was judged by the amount of 5-hydroxyindole excreted in 24-hour urine of the host mice, (C57L×A)F_1 female, in the case of Furth mastcytoma cells, and the body weight increase rate in ddN male mice in the case of Ehrlich ascites cells after transplantation of the cultured cells. Observations were made 8-10 days after transplantation of the cells. X-Ray irradiation of the cells was made in a dose of 1000 R, and the number of cells transplanted was 4×10^6 cells/0.5 ml in the case of Furth cells and 20×10^6 cells/0.5 ml in the case of Ehrlich cells. Protective effect of 5-hydroxytryptophan was seen in the case of Furth cells in a dose of 1 mole/25000 cells but not in the case of Ehrlich ascites tumor cells.
社団法人日本薬学会の論文
1969-10-25