実験的クモ膜下出血犬における血液凝固系の変動と血小板抑制剤(塩酸チクロピジン)の効果

概要

論文の詳細を見る
It has been reported that vasospasms are frequently associated with changes in blood coagulability, which may play an important role in symptomatic vasospasms. To verify this point experimental studies were performed to analyze the changes of blood coagulability after subarachnoid hemorrhage (SAH) and to investigate the effect of the platelet coagulation inhibitor. SAH was produced by cisternal injection of autogeneous arterial blood in 50 mongrel dogs. Blood sampling and angiography were carried out every 1-3 days and the basilar artery was histologically examined 7-8 days after the bleeding. No changes of prothrombin time, partial thromboplastin time and activated coagulation time were noted before or after the bleeding and also by the oral administration of the platelet aggregation inhibitor. Increase of the platelet aggregation rate was noted from one day after SAH. Increase of fibrinogen on day 1-3 and return to the basal value on day 7-8 after SAH were also observed. These changes were prevented by oral administration of the platelet aggregation inhibitor though no angiographical and histological changes were induced. These findings indicate that this drug has the potential of preventing symptoms of vasospasms after SAH.
日本脳神経外科学会の論文
1985-10-15