頭蓋咽頭腫における石灰化巣形成過程の電子顕微鏡的観察

概要

論文の詳細を見る
The calcification process in eight cases of adamantinomatous craniopharyngioma was studied at the ultrastructuraJ level.The neoplastic cells,which constituted the internal and intermediate zones of the tumor,frequently displayed abundant cytoplasmic tonofibrils and,occasionally,keratinization.In most of the degenerated keratinized cells,the intracytoplasmic organelles had disappeared.In these cells,membrane-bound vesicles measuring approximately 0.15 to 0.5 μm in diameter,were frequently seen among the numerous tonofibrils.Needle-like,mineralized crystals were precipitated some vesicles.Tiny,calcified vesicles were sometimes aggregated and had coalesced with the adjacent tonofibrils to form a large,calcified mass.These findings suggest that membrane-bound vesicles are derived from degenerated keratinized cells and play an important role as initial nidi of calcification in craniopharyngioma.Remnants of tonofibrils of degenerated cells may also serve as foci of mineralized crystal deposition.
日本脳神経外科学会の論文
1988-02-15