エンドトキシンショックに対する血液浄化法,血液透析の施行経験

概要

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Six neonates in the endotoxin shock were treated by hemoperfusion and/or hemodialysis. Three of them recovered from shock and survived. Three cases died. Two out three dead cases needed the resuscitation when they came to our hospital. Thrombocytopenia was improved in five cases. Metabolic acidosis returned to normal range in our cases. B.U.N. and creatine were also improved in five cases and in six cases respectively. But urine volume was not restored in three dead cases. Measurement of serum endotoxin level showed disappearance or decreasing tendency after those procedures. Charcoal filter DHP-1, which was clinically used for hemoperfusion, was tested experimentally for it's effectiveness to absorve endotoxin in saline. Our in vitro experiment demonstrated that endotoxin of 0.5μg/ml concentration in saline was completely cleared within 30 minutes by charcoal filter DHP-1. Hemoperfusion and hemodialysis were considered to be promising for the treatment of endotoxin shock.
日本小児外科学会の論文
1982-04-20