骨粗鬆症モデルラット骨量に対する生薬升麻を含む漢方製剤の効果

概要

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Since the methanol extract of Shoma (Cimicifugae Rhizome) has been known to reduce the enhanced resorption of bone, we investigated the effect of Otsuji-to (OT; Yi-Zi-Tang) and Shoma-kakkon-to (SKT; Sheng-Ma-Ge-Gen-Tang) including "Shoma" as a component, on bone mass in ovariectomized rats. Female Sprague-Dawley rats were ovariectomized at 9 weeks of age and divided into 5 groups of 8 rats each at 44 weeks of age; i.e. 1) ovariectomized control ratss (OVX-Control), 2) ovariectomized, OT-treated rats (OVX-OT), 3) ovariectomized, SKT-treated rats (OVX-SKT), 4) ovariectomized, 17α-ethynylestradiol-treated rats (OVX-E) and 5) normal control rats (Normal-Control). Ovariectomy significantly reduced the bone mineral density (BMD) of the whole tibia (p<0.05). Eight-week treatment with E or OT enhanced the BMD of the metaphysis of tibia compared with that in the OVX-Control group (p<0.05). Plasma alkaline phosphatase (ALP) activity and calcium concentration in OVX-OT or OVX-SKT groups were elevated compared with those in the OVX-Control group (p<0.005). In contrast, plasma ALP activity in the OVX-E group was reduced compared with that in the OVX-Control group (p<0.005), though the plasma calcium concentration was increased (p<0.005). In conclusion, it is suggested that OT-treatment augments tibial BMD via a mechanism different from that of E.
2001-06-20