イソソルビドの体内動態および希釈投与による影響

概要

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We investigated the influence of pharmacokinetics on the dilution of isosorbide (ISOBIDE^<[○!R]>) in three healthy male volunteers. They received both undiluted ISOBIDE^<[○!R]> and 5-times-diluted ISOBIDE^<[○!R]> Gas chromatodraphy was used to measure the serum concentration and excretion rate of isosorbides in urine. The results showed thet the pharmacokinetic parameters did not significantly differ between to undiluted ISOBIDE^<[○!R]> and 5-times-diluted ISOBIDE^<[○!R]> (elimination rate constant of 0.101 hr^<-1> and 0.106 hr^<-1> , distribution volume of 0.660 l/kg and 0.660 l/kg, half-life of 6.84 hr and 6.57 hr, and excretion amount in urine of 79% and 80%) . Therefore, these results indicate that the effect of pharmacokinetics on 5-times-diluted isosorbide remains unchanged.
日本医療薬学会の論文
1996-04-10