他剤配合による塩化リゾチーム製剤の配合変化

概要

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The compatibility of lysozyme syrup with some commercial syrup preparations was investigated. When the lysozyme syrup Was mixed with each of the five syrups (hydroxyzine pamoate, ketotifen fumarate, tranilast, cherry bark extract, dextromethorphan hydrobromide and ambroxol hydrochloride) the lysozyme activity was decreased by 50% after 14 days at 30℃ in the light. By mixing lysozyme with cherry bark extract, dextromethorphan hydrobromide or ambroxol hydrochloride, the lysozyme activity remained stable for 14 days under the condition of 4℃ in the dark. Although sediment was produced at 7 days by mixing lysozyme syrup with oxatomide, the lysozyme activity did not change. These results indicate that the mixing of lysozyme syrup with hydroxyzine pamoate, oxatomide, ketotifen fumarate and tranilast is not recommendable even at 4℃ in the dark.
日本医療薬学会の論文
1995-06-10