活性炭懸濁液の中毒薬物吸着能に及ぼす滅菌処理および長期保存の影響

概要

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Three kinds of activated charcoal suspensions using a laxative solution as a dispersion medium were prepared to provide for acute intoxication. Used in the dispersion medium were 13.6% magnesium citrate, 15.0% magnesium sulfate and 75.0% D-sorbitol. These suspensions and a suspension using an isotonic sodium chloride solution as a dispersion medium (control) were sterilized for the purpose of long-term storage. The adsorption power was tested by a modified adspoption test of the JP XII medicinal carbon and a modified one of the USP XXII activated charcoal. The suspensions of magnesium citrate and D-sorbitol failed in the methylene-blue adsorption test of JP XII. The other suspensions passed every adsorption test. The adsorption power of the suspensions for phenobarbital, which is often responsible for drug poisoning, was estimated to be ca. 300 mg drug per gram of charcoal, and was stable over two months at room temperature. After 30 months of storage, the adsorption power decreased to 92% of its initial value while the magnesium sulfate suspension observed a reduction of 40%. We conclude that these suspensions are suitable activated charcoal formulations for provision to the emergency room due to the adsorption power and stability.
1994-06-20