The Effectiveness of G-CSF on the Incidence of Febrile Neutropenia and Antibiotic Usage in Gynecologic Cancer Patients Receiving Chemotherapy.:Patients Receiving Chemotherapy

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The efficacy of recombinant granulocyte-colony stimulating factor (G-CSF) has been shown in clinical trials. However, the high cost of G-CSF has led to concern about its beneficial effects in clinical practice.<BR>Reviewing medical records of 57 gynecologic cancer patients with 250 courses of cytotoxic chemotherapy, we evaluated the effectiveness of G-CSF administration on the incidence of febrile neutropenia and on antibiotic usage. The courses were divided into two groups: "case" (post-marketing of G-CSF) and "control" (pre-marketing of G-CSF). Information on the blood cell count, regimen, age and number of days since the operation for both cases and controls was obtained from their medical records. Data of cases and controls were compared.<BR>In the analysis of odds ratios from the logistic regression model, there were no significant differences between case and control groups in terms of the incidence of febrile neutropenia and antibiotic usage for the treatment of febrile neutropenia. On the other hand, the incidence of antibiotic usage for the prevention of infection was significantly high in the case group (p<0.05).<BR>These results may indicate that the effectiveness in G-CSF usage is probably dependent on physician's decision-making in the administration of the above agents. Further studies are warranted on the effectiveness of pharmaceutical agents in clinical practice as well as clinical trials.
一般社団法人日本臨床薬理学会の論文

The Effectiveness of G-CSF on the Incidence of Febrile Neutropenia and Antibiotic Usage in Gynecologic Cancer Patients Receiving Chemotherapy.:Patients Receiving Chemotherapy

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