リンパ節識別用染色化剤としてのO/W型クロロフィル乳剤の調製

概要

論文の詳細を見る
An O/W type chlorophyll emulsion was prepared as a color marker to identify the lymph nodes. The emulsion consisted of chlorophyll oil, sesame oil, glycerin, water and surfactants. The final formulation containing 4% of phosphatidylcholine and 1.5% of polysorbate 80 as surfactants was stable over seven days at room temperature. The emulsion was endoscopically injected into the gastric submucosa of the dog. Laparotomy after two days of injection of emulsion showed that the lymph nodes have been stained green. Histological findings of the liver, kidneys, pancreas, lungs and heart of the rats did not show the toxic effect; one week after intraperitoneal injection of 2ml/kg of the emulslon Therefor, the chlorophyll emulsion was an effective and safe color marker to identify the lymph nodes from their surrounding tissues during the surgery of the malignancy.
日本医療薬学会の論文
1993-02-20