食道静脈瘤の内視鏡的栓塞療法 : (2)造影剤を配合した栓塞剤の安定性

概要

論文の詳細を見る
In our previous report (1st Report), study was made on the stability of an injectable solution (EOMA) to be used in injection sclerotherapy (endoscopic embolization) for esophageal varix, which was prepared by mixing Ethanolamine Oleate Injection (EO) with a contrast medium, meglumine amidotrizoate injection. In the present study (2nd Report), another injectable solution (EOI) was prepared by mixing EO with non-ionic iopamidol injection. With sterilized and unsterilized samples of EOI, observation was made on time-course changes in appearance, pH and the volume of each component for 8 weeks. Also, mucosity and osmotic pressure of EOI, EO and EOMA were measured. Except for slight development of a brown color in sterilized samples of EOI, no major change was observed in each test item during the 8-week storage in a dark and cold place. The results suggest that EOI is stable for at least 8 weeks in a dark, cold place. As the mucosity of EOI is lower than that of EOMA, EOI has great advantages in the filtration operation in manufacturing process of injections or in injection into affected parts.
日本医療薬学会の論文
1984-12-20