食道静脈瘤の内視鏡的栓塞療法 : 栓塞剤の安定性

概要

論文の詳細を見る
As an agent for injection sclerotherapy (endoscopic embolization) for esophageal varix, an injectable solution (EOMA) was prepared by mixing ethanolamine oleate injection (EO) with meglumine amidotrizoate injection. For the stability evaluation of EOMA and EO, tests were performed with the samples prepared under 4 different conditions to observe changes in appearance with time, pH, oleic acid content, iodine value, benzyl alcohol content and amidotrizoic acid content for 8 weeks. No abnormality was observed in appearance of all the samples of EOMA and EO, except slight development of a brown color in sterilized samples of both injections .Almost no change was observed in pH of both EOMA and EO during the 8-week test period. The pH of EOMA was lower than that of EO, since EOMA contained meglumine amidotrizoate injection of pH of about 6.5. No major change was observed in oleic acid contents and iodine values of both EOMA and EO during the test period, nor was seen any difference in those values among samples prepared under different conditions, and benzyl alcohol also showed similar results. Also amidotrizoic acid mixed in EOMA showed almost no change throughout the 8 weeks. These results suggest that both EOMA and EO, prepared in any condition, are stable for 8 weeks, if they are preserved in a dark and cold place.
日本医療薬学会の論文
1984-02-20