パラコートの活性炭吸着に及ぼす抗凝固剤の影響

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The effects of three anticoagulants, which are heparin sodium, nafamostat mesilate and dalte parin sodium, on paraquat adsorption to activated charcoal (AC) and on paraquat desorption from paraquat-AC complex were studied in vitro. Each 10 ml of anticoagulant solution and 100 mg of AC was added to the 10 ml of paraquat dichloride solutions ranging in concentration from 150 to 1000 μg/ml, and the mixture was incubated at 37℃ for 24 hours. The concentrations of paraquat unadsorbed on AC in the presence of nafamostat mesilate were 10-73% higher than that in the isotonic sodium chloride solution (control). Furthermore, the paraquat concentrations in the mixture were increased by the rise in nafamostat mesilate which coexisted with paraquat. However, the paraquat concentrations in the presence of the other two anticoagulants were almost equal to that in the control. Each 10 ml of nafamostat mesilate solutions was added to the AC pre-equilibrated with 10 ml of paraquat dichloride solutions (200 and 700 μg/ml), and the mixture was incubated at 37℃ for 24 hours. The concentrations of paraquat unadsorbed on AC and desorbed from AC in the mixture was 14-54% higher than that in the control. We concludethat nafamostat mesilate is an unsuitable anticoagulant for the prevention of clotting extracorporeal hemoperfusion with AC in instances of paraquat poisoning, although dalteparin during sodium appears to be an effective anticoagulant because no effect is exhibited on paraquat adsorption and little hemorrhage results in patients.
日本医療薬学会の論文
1994-02-20

パラコートの活性炭吸着に及ぼす抗凝固剤の影響

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