調剤工程および服用時の薬剤損失 : ジゴキシン製剤をモデルにして

概要

論文の詳細を見る
It is well known that the bioavailability of digoxin is dependent on the dosage forms and the ground tablets of digoxin are also more frequently ordered instead of the powdered form for prescriptions. In the present study, the weight loss of the drug, due to the dispensing process and adherence to either the package or the measuring cup, was studied. Three dosage forms of digoxin including ground tablets, powders and elixir, were used as the model forms. Simulative dispensing was carried out using the conventional methods. For ground tablets and powders, a 2 to 3% weight loss in the dispensing process, and a 7 to 8 % weight loss due to adherence to the package were observed. In the case of the elixir, a 0.3 to 0.4% weight loss in the dispensing process, and a 1.3 to 1.4% weight loss due to adherence to the measuring cup and the plastic bottle was observed. We thus conclude that the elixir is the most suitable digoxin dosage form for children who have difficulty swallowing tablets due to its smaller weight loss.
日本医療薬学会の論文
1999-06-10