グリセリン添加白糖・ポビドンヨード製剤の開発

概要

論文の詳細を見る
Improvement of povidone-iodine sugar (PI) formulation which is used for treatment of decubitus and wound was attempted. Three model formulations and the existing hospital preparation (IS) were compared with respect to characteristics, pH, osmotic pressure, hardness and effective iodine. When PIs were kept at room temperature without light for 14 days, the hardness of each increased. It was found that osmotic pressure and hardness could be controlled by the addition of glycerin. An optimum formulation of PI containing glycerin (IGS) was chosen based on the restriction of hardness and osmotic pressure. The usefulness of IGS was compared with IS through a questionnaire sent to doctors and pharmacists. As a result, the clinical effect of IGS was the same as IS, but the usefulness, spreadability and sensitivity on use of the former were superior to those of IS.
日本医療薬学会の論文
1994-06-20