水中の直接変異原MXの生成と毒性発現の機構 : 第11回公開シンポジウム : 環境変異原の活性発現と抑制の化学的機構

概要

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A potent direct mutagen, 3-chloro-4-dichloromethyl-5-hydroxy-2 (5H) -furanone (MX) , has been detected from tap water, swimming pool water and domestic effluent after chlorine disinfection. MX induced glandular stomach cancer on Wistar rats in two stage carcinogenesis test with N-methy-N'-nitro-N-nitrosoguanidine. After intragastrically administration of MX to Wistar rats, the liver and stomach were applied to ^<32>P-postlabeling method. DNA-adducts were formed with and without 2-amino-3-methyl imidazo-[4, 5-f]-quinoxaline (MeIQx) which is found in broiled meats and fish. To detect the precursors of MX contained in domestic effluent, several materials were chlorinated and analyzed by GC-MS-SIM method. Polyphenolic compounds containing (±) catechin and diosmin were identified. These results show that MX may give adverse effect on aquatic organisms and also on human beings as a potent mutagen and carcinogen in the water samples. Therefore, the risk assessment and risk management of MX will be important task in near future.
日本環境変異原学会の論文
2000-12-22