殺虫剤サリチオン(2-methoxy-4H-1,3,2-benzodioxaphosphorin-2-sulfide)の代謝と毒性

概要

論文の詳細を見る
Salithion, an insecticide analogous to TOCP-metabolite, did not cause ataxia in chickens injected with a total of 80 mg/kg in daily doses. Salithion-^<32>P was synthesized and administered orally to mice and topically to houseflies. Autoradiography of body slies and Tadioassay of whole body and excreta indicated that Salithion was rapidly decomposed in mice and excreted. Chloroform-soluble ^<32>P in the body was only 2.4% of the administered ^<32>P at three hours after treatment. On the other hand, Salithion persisted in the houseeflies for a relatively long time. More than 4% of the applied or 10% of the absorved Salithion was found in the chloroform-soluble fraction of houseflies at 24 hours after treatrment. Besides Salithion, only its oxo analog was detected in the chloroform-soluble fraction by the autoradiogram of thin layer chromatography.
日本応用動物昆虫学会の論文
1970-12-25