哺乳動物におけるpentachlorophenol(PCP)の代謝

概要

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Sodium salt of 14C-labeled pentachlorophenol (PCP) was synthesized and administered to some mammals. In the urine of rabbit administered orally with PCP-Na, considerable amounts of a strong acid metabolite and a little amount of chloranil, which was characterized by thin-layer chromatography, were discovered besides free PCP. The acid metabolite (A-1) was isolated and characterized as pentachlorophenyl β-glucuronide. It decomposed to give PCP by heating or by the condition to take mass spectrum. It was easily hydrolyzed with diluted hydrochloric acid (0.1%) to give PCP, glucuronic acid and glucuronolactone. The transformation of glucuronic acid to the lactone took place in the condition of acid hydrolysis of A-1. A-1 was also hydrolyzed by the action of β-glucosidase without the production of the lactone. A-1 was a major metabolite in the excreta of rat administered subcutaneously. The production of chloranil was observed in the internal organs of mouse two hours after intraperitoneal administration.
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