PATHOGENICITY OF NEGISHI VIRUS IN MICE CHARACTERIZED BY AGE OF SUSCEPTIBILITY, ROUTES OF INOCULATION AND GROWTH OF THE VIRUS IN TISSUES

概要

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Pathogenicity of Negishi virus, a member of the tick borne encephalitis virus group isolated in Japan, was examined in mice. Weaning mice were highly susceptible to lethal infection of Negishi virus upon both intraperitoneal (ip) and subcutaneous (sc) inoculations, and less than 1.0 PFU per 0.1ml of virus was sufficient to kill 50% of the mice in both instances. On the other hand, weaning mice were relatively resistant to peroral (po) infection of the virus, and the lethal dose 50 was 10^<7.5>PFU. Resistance of ageing mice was observed when the mice were inoculated with Negishi virus via the ip route. Negishi virus first appeared in the spleen of the mice inoculated via the sc route. The highest titer of Negishi virus (10^<4.0> to 10^<5.0>) was obtained in the brains of mice infected via the sc and ip routes. The virus was not detected in the blood during the course of infection. A relatively high titer of Negishi virus (10^<3.0> to 10^<4.0>) persisted in the small and large intestines of infected mice.
北海道大学の論文
1983-03-15