Milrinone Reduces Cerebral Vasospasm After Subarachnoid Hemorrhage of WFNS Grade IV or V
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概要
- 論文の詳細を見る
The preventative effect of cisternal irrigation with milrinone against vasospasm was evaluated in 12 patients with subarachnoid hemorrhage (SAH) of World Federation of Neurosurgical Societies grade IV or V treated between September 1999 and September 2000. All aneurysms were clipped or embolized within 72 hours of the onset of SAH. Inlet and outlet tubes were placed in either the supratentorial cisternal space, lateral ventricle, or spinal subarachnoid space. Lactated Ringer solution containing urokinase (120 IU/ml), ascorbic acid (3.5 mg/ml), and milrinone (3.6 μg/ml) was continuously infused at 30 ml/hr for as long as 2 weeks. Angiographical vasospasm was detected in only two of the 11 patients who received milrinone irrigation and underwent postoperative angiography. Vasospasm may have resulted from irrigation obstruction associated with pneumocephalus in one patient and clot in the sylvian fissure in the other patient. The outcome of the milrinone irrigation therapy was significantly better than that of the conventional therapy. This study suggests that cisternal irrigation with milrinone is safe and effective, and reduces the occurrence of vasospasm in patients with poor grade aneurysmal SAH.
- 日本脳神経外科学会の論文
- 2004-08-15
著者
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HASHIMOTO Nobuo
Department of Neurosurgery, Kyoto University Graduate School of Medicine
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YAMAGATA Sen
Departments of Neurosurgery, Faculty of Medicine, Kyoto University
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NOZAKI Kazuhiko
Department of Neurosurgery, Shiga University of Medical Science
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Hojo Masato
Department of Neurosurgery, Graduate School of Medicine, Kyoto University
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KIKUTA Ken-ichiro
Department of Neurosurgery, Kyoto University Graduate School of Medicine
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Nozaki Kazuhiko
Department Of Neurosurgery Kyoto University Graduate School Of Medicine
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Nozaki Kazuhiko
Department Of Neurosurgery Faculty Of Medicine Kyoto University
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Kikuchi Kenji
Department Of Neurosurgery Kyoto University Graduate School Of Medicine
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Dorsch Nicholas
Department Of Neurosurgery Westmead Hospital
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Dorsch Nicholas
Department Of Neurosurgery Clinical Neurophysiology Unit Westmead Hospital University Of Sydney
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Yamagata Sen
Department Of Neurosurgery Kurashiki Central Hospital
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GOTO Yasunobu
Department of Neurosurgery, Faculty of Medicine, Kyoto University
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Goto Yasunobu
Department Of Neurosurgery Kyoto University Graduate School Of Medicine
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Goto Yasunobu
Department Of Neurosurgery Faculty Of Medicine Kyoto University
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ARAKAWA Yoshiki
Department of Neurosurgery, Kurashiki Central Hospital
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Hojo Masato
Department Of Neurosurgery Kurashiki Central Hospital
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Hachiya Noriyuki
Department Of Neurosurgery Kyoto University Graduate School Of Medicine
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Hashimoto Nobuo
Department Of Cerebrovascular Surgery National Cordiovascular Center
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Kikuta Ken-ichiro
Department Of Neurosurgery Kyoto University Graduate School Of Medicine
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Kikuta Ken-ichiro
Department Of Neurosurgery Kurashiki Central Hospital
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Kikuta Ken-ichiro
Department Of Neurosurgery Faculty Of Medical Sciences University Of Fukui
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Arakawa Yoshiki
Department Of Neurosurgery Kurashiki Central Hospital
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De Oliveira
Instituto De Ciencias Neurologicas
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De Oliveira
Institute Of Neurological Sciences (icne)
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CHADDAD Feres
Instituto de Ciencias Neurologicas
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HOJO Masato
Department of Neurosurgery, Kurashiki Central Hospital
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de Oliveira
Institute of Mathematical Sciences and Computing, University of São Paulo
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