<原著>慢性腎不全患者における血液透析期間の血清補体系への影響(自然科学系)

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Serum complement system specific for patients with chronic renal failure under hemodialysis (HD) was studied by determining the serum complement levels in 204 patients under hemodialysis. This study focuses on the influence of the duration time of HD on complement levels in patient sera. CH50 and ACH50 levels were assayed for complement functional activity, and protein levels of C3 and factor D were determined by ELISA in patient sera. The following were revealed: 1) Serum factor D levels in patients of any period of HD were much higher than those of normal human volunteers (NHV); 2) in the induction period (0-3 months) of HD, ACH50 levels were significantly higher than those of NHV, but there was no significant difference in levels of CH50 and C3 between the patients and NHV; 3) in the stable period (3-120 months) of HD, elevated ACH50 levels decreased but were still higher than those of NHV; and 4) in the prolonged period (>120 months) of HD, C3 and CH50 levels decreased significantly from those in the stable period and the levels of ACH50 and CH50 also, in general, decreased. These differences in complement levels of patients at various duration times of HD were likely to be due to i) accumulation of factor D in serum because of the metabolic disturbance of factor D; ii) alternative pathway complement activation by the accumulated factor D; iii) elevated complement synthesis as acute phase proteins by the continuous inflammation; and iv) decreased complement synthesis due to disturbed general conditions.
大阪府立大学の論文
2001-03-30

<原著>慢性腎不全患者における血液透析期間の血清補体系への影響(自然科学系)

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