補体学入門 : Cold Activation現象の発見から現在の問題点まで(自然科学系)

概要

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This short review is for beginners in complementology. The complement system is composed of 30 kinds of physiological proteins: 14 serum complement components; 6 serum inhibitors; 4 membrane inhibitors; and 6 complement receptors on the cellular membrane. The system plays two important roles in host defence, one being the elimination of microorganisms and the other the clearance of other antigens from tissue and blood. Complement activation proceeds through the classical pathway or the alternative pathway, resulting in the generation of biologically active fragments of complement components. Cold-induced activation of serum complement is a unique phenomenon. It is observed occasionally in clinical laboratories, characterized by normal complement activity (CH50) in plasma but low CH50 in serum. This indicates that serum CH50 does not always reflect the complement level in vivo. In this phenomenon, complement activation proceeds through the classical pathway when the blood or serum is allowed to stand at low temperature, even at room temperature. The discovery, the significance and the mechanism of this phenomenon are detailed.
大阪府立大学の論文
1997-12-31