<原著>ネブライザーによる薬剤の扁桃及び血中への移行について

概要

論文の詳細を見る
Nebulization has been conventionally used as one of the conservative therapies for tonsillitis. However, nebulization absorption route and effect have not yet been explicated. In this study, ultra- and jet-nebulizations of Dibekacin (DKB) were performed on 34 cases of tonsillitis, and its blood and tissue concentrations were determined. The results indicated that the blood DKB concentration was higher in the case of a jet-nebulizer than an ultranebulizer, while the tissue DKB concentration was conversely higher in the case of an ultranebulizer than a jet-nebulizer in habitual tonsillitis. On nebulizing rolitetracycline (Hostacyclin) which emanates fluorescence, it was confirmed that the nebulized particles were absorbed from the epithelial pores of the tonsillar lacuna into the germinal center.
1984-12-30