<原著>扁桃誘発試験による末梢血中および扁桃組織内のリンパ球サブセットの変化について

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There have been still many unclarified points concerning the functional mechanisms on provocation test of tonsils. Following the ultrashort provocation test of tonsils changes of the components of leucocytes were studied. A comparative study by monoclonal antibody method was made on the lymphocyte subsets (OKT4,OKT8,and OKIa1) of peripheral blood and intratonsillar tissues before and after the provocation and on those of intratonsillar tissues of the provocated tonsil on one side and the nonprovocated on the other. The subjects are 144 cases who underwent the examination at the Department of Otolaryngology, Kinki University School of Medicine from January to December, 1984 : Child and adolescence group younger than 20 years of age consists of 106 cases, adult group 20 or older comprising 38. Seventy seven cases are male and 67 female. The subjects were classified into three groups, namely, habitual angina, focal infection and simple hypertrophy of tonsils. Changes of peripheral blood components except for OKIa1 in the group below 20 years revealed significant increase in habitual angina, focal infection and simple hypertrophy of the tonsil in that order. As regards intratonsillar changes, no significant change was observed, but OKT4 values decreased in nonprovocated tonsils of adult group. Monoclonal antibody peroxidase stain revealed that the intratonsillar distribution of OKT4 in provocated tonsil decreased, compared with the nonprovocated. In conclusion, significant changes of the lymphocyte subsets of peripheral blood and tonsillar tissues were observed in our studies. These immunological observations following provocation test of tonsils may be valuable for explaining the functional mechanisms of tonsillitis. The increase in lymphocytes of peripheral blood may be the most helpful indicator for tonsillectomy.
近畿大学の論文
1985-09-25

<原著>扁桃誘発試験による末梢血中および扁桃組織内のリンパ球サブセットの変化について

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