<原著>気管支喘息の気道狭窄に対するテオフィリン血中濃度とその効果に関する検討

概要

論文の詳細を見る
Theophylline is used for the treatment of asthma and other various obstructive lung diseases, but its serum concentration is greatly variable from patient to patient. There are several reports on in vivo dynamics and effective serum concentrations of theophylline. In this study, we administrated theophylline to patients with asthma in various combinations and made sequential observation on its serum concentration and improvement of lung function, as well as on the changes of chemical substances within the organism in some of the patients. Theophylline, when administrated by rapid intravenous injection, presented a serum concentration pattern of one-comparament system with FEV_<1.0> improvement rate showing some time-lag. Theophylline administrated by intravenous infusion presented a serum concentration pattern of multi-comparament system, with FEV_<1.0> improvement rate showing a nearly dose-dependent response. However, there is not always such a relationship in V_<50> and V_<25> of flow volume curves. These results suggested that prior to the administration of theophylline we should establish an optimal administration schedule by grasping the half life of in vivo dynamics and its clearance in individual patients.
近畿大学の論文
1984-03-25