<原著>Silicone Oil Surface LungのPV曲線

概要

論文の詳細を見る
There are clear differences in the experimental results of lung surface tension in vitro and in situ studies. As one of the reasons, it can be stated that the saline-filled PV relation does not express the non-surface component of the total P-V relation. In the present study P-V curves of the excised rabbit lung wetted with silicone oil which does not cause the swelling of pulmonary tissues and leakage were recorded, and the lung surface tension in situ was calculated from the above results. The saline P-V curve did not show that of the pulmonary tissues, and the true P-V curve was shifted toward the high pressure side. γ_<max> was about 47 dyne/cm (at 22 to 24℃) and γ_<min> was nearly 0. The change of the lung capacity is not isotropic. However, whether the change is isotropic or not is not the main reason to induce the difference between in vitro and in situ values. The lung capacity is increased not only by the increase of individual alveolar volumes, but also by the increase of the number of inflated alveoli caused by so-called pop-up opening of collapsing alveoli. The opening of a severe edema lung depends on the surface tension of substances at the peripheral airway and on its inner diameter.
近畿大学の論文
1979-06-25