<原著>気道過敏性に関する研究 : 気管支喘息におけるProstaglandin F_<2α>とAcetylcholineによる気道過敏性について

概要

論文の詳細を見る
The bronchial hypersensitivity in bronchial asthma was studied by measuring the changes of forced expiratory volume one second (FEV_<1.0>) and flow-volume (F-V) curve with prostaglandin (PG) F_<2α> or acetylcholine (Ach) inhalation in 24 patients with asthma, 12 patients with respiratory diseases without asthma and 10 normal subjects in total of 46 cases and various relating factors to PGF_<2α> and bronchial asthma were also investigated. The following results were obtained : 1. The threshold of PGF_<2α> inhalation in patients with asthma was lower than in the patients with respiratory diseases without asthma and the normal subjects (P<0.0001). 2. The threshold of PGF_<2α>, inhalation was correlated with the age of onset (r=0.4482,P<0.05) and the duration of asthma in atopic type (P<0.025), on the other hand the threshold of PGF_<2α> inhalation in atopic asthma was lower than in infectious asthma (P<0.01), and there was no significant correlationship with air pollution. 3. The threshold of PGF_<2α> inhalation was correlated with the threshold of Ach inhalation in the patients with asthma (r=0.887,P<0.005).
近畿大学の論文
1981-12-25