<原著>摘出肺におけるPV曲線とDEFINING TLC

概要

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An excised lung is often used to study the mechanism of the lung. There is some possibility that the method to measure the total lung capacity (TLC) has influences on the experimental result. We used an excised lung of a rabbit, studied P-V curves at 23 to 25℃, and at 27 to 30℃ in two groups of lungs, namely, normal and hydration lungs, and worked out a measuring method of "defining TLC" having extremely high reproducibility. The results are as follows : The relation between the TLC at the second cycle (second TLC) and the TLC at the first cycle (first TLC) was expressed with a regression line with an extremely high correlationship. When a lung is inflated to a suitable TLC, the first TLC coincided perfectly with the second one. In a normal lung there was a perfect superimposition in P-V curves from the second cycle on. When the second TLC does not coincide with the first one accurately, the ideal "defining TLC" can be calculated. Its simple calculation method was also given. When excised lungs are used, there is a risk that different results are obtained from similar experiments, unless the TLC is strictly determined. By using the "defining TLC" described in the present study, such a risk can be avoided.
近畿大学の論文
1979-06-25