<原著>喫煙習慣者と肥満者におけるplasminogen activator inhibitor type-1 (PAI-1)および炎症性サイトカインに関する研究

概要

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Smoking is one of the risk factors for cardiovascular disease. Plasminogen activator inhibitor-1 (PAI-1) and interleukin-6 (IL-6) are related to thrombosis and inflammation, respectively. Recently, adipocytes have been reported to be not only energy storage cells but also endocrine cells secreting a variety of bioactive adipocytokines such as PAI-1 and IL-6. We investigated the plasma levels of PAI-1 and IL-6 in 68 healthy subjects who visited a clinic in Izumi-cho, Izumi-ku, Yokohama City, for a health check up. The subjects were divided into four groups (smoking/obese, n=15 ; smoking/non-obese,n=15 ; non-smoking/obese, n=19 ; and non-srnoking/non-obese,n=19). Smoking/obese group showed the highest plasma PAI-1 level, whereas non-smoking/non-obese group showed the lowest (18.0±11.5 ng/ml versus 4.8±2.9 ng/ml ; p<0.01). PAI-1 level was positively correlated to both body mass index and cigarette consumption (Brinkman Index). Moreover, PAI-1 was also correlated with IL-6 level. These results indicate that smoking and obesity increase the plasma level of both PAI-1 and IL-6. Overlapping of risk factors such as a smoking habit and obesity might contribute to the pathogenesis of thrombosis.
愛知医科大学の論文
2003-06-15