肥厚性瘢痕,ケロイド組織におけるmast cell surface antigen-1(MASA-1)の発現

概要

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Hyper trophic scar and keloid, characterized by the hyperplasia of the fibrotic tissues, are chronic inflammatory diseases, which develop in the process of wound healing with an unknown etiology. In recent years, mast cells are reported to be associated with chronic inflammatory diseases such as interstitial pneumonia and sarcoidosis, and the mast cell granule component histamine and tryptase have been shown to promote the proliferation of fibroblasts. These reports suggest that mast cells are involved in the pathogenesis of hypertrophic scar and keloid. Recently, we cloned the mast cell surface antigen-1 (MASA-1), which is specifically expressed on mast cells. In the present study, the expression of MASA-1 on mast cells was investigated immunohistochemically in the lesional tissues of hypertrophic scar and keloid. Specimens of normal skin, hypertrophic scar and keloid were obtained from 7 patients. The density of MASA-1 positive cells and methachromatic cells significantly increased in the upper dermis of hypertrophic scar and keloid. MASA-1 positive cells corresponded well to mast cells with sparsely granulated cells considered to be degranulated mast cells. These findings indicate that the activation of mast cells in the upper dermis plays a role in the pathogenesis of hypertrophic scar and keloid, and MASA-1 was considered to be a specific marker for the activated mast cells.
2005-03-10