Usefulness of CT-MRI Fusion in Radiotherapy Planning for Localized Prostate Cancer
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概要
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We compared the prostate volumes and rectal doses calculated by CT and CT-MRI fusion, and verified the usefulness of CT-MRI fusion in three-dimensional (3D) radiotherapy planning for localized prostate cancer. Three observers contoured the prostate and rectum of 13 patients with CT and CT-MRI fusion. Prostate delineations were classified into three sub-parts, and the volumes and distances to the rectum (PR distance) were calculated. 3D radiotherapy plans were generated. A dose-volume histogram (DVH) was constructed for the rectum. The intermodality and interobserver variations were assessed. CT-MRI fusion yielded a significantly lower prostate volume by 31%. In the sub-part analysis, the greatest difference was seen for the apical side. The PR distance was significantly extended by 3.5-mm, and the greatest difference was seen for the basal side. The irradiated rectal volume was reduced in the CT-MRI fusion-based plan. The reduction rates were greater in the relatively high-dose regions. The decrease of the prostate volume and length alteration of the distance between the prostate and rectum were correlated with the decrease of the irradiated rectal volume. The prostate volume delineated by CT-MRI fusion was negatively correlated with the decrease of the irradiated rectal volume. CT showed a tendency towards overestimation of the prostate volume and underestimation of the PR distance as compared to CT-MRI fusion. The rectal dose was significantly reduced in CT-MRI fusion-based plan. Using CT-MRI fusion, especially in cases with a small prostate, the irradiated rectal volume can be reduced, with consequent reduction in rectal complications.
- 2011-11-16
著者
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Hoshi Hiroaki
Department Of Radiology Gifu University
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Iida Takayoshi
Department Of Radiology Gifu Municipal Hospital
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Iida Takayoshi
Department Of Applied Chemistry And Biotechnology Faculty Of Engineering Niigata Institute Of Techno
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Tanaka Hidekazu
Department Of Internal Medicine Iii Osaka Medical College
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Hayashi Shinya
Department Of Chemical Engineering Kobe University
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Ohtakara Kazuhiro
Department Of Neurosurgery Mie University School Of Medicine
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Ohtakara Kazuhiro
Department Of Radiology Gifu University Graduate School Of Medicine
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Hayashi Shinya
Department Of Radiology Gifu University Hospital
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Hoshi Hiroaki
Department Of Radiology Gifu University Hospital
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Tanaka Hidekazu
Department Of Earth And Planetary Sciences Faculty Of Science Tokyo Institute Of Technology
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Tanaka Hidekazu
Department Of Radiology Gifu University Hospital
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Tanaka Hidekazu
Department Of Chemistry And Chemical Biology Gunma University
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